Of the 34 patients who entered into the study, 15 patients (44.1%) had primary admission on ICU, the others being transferred from other hospitals to the ICU “Casa Austria”, after more than 24 hours from the time of injury. Other common injuries in polytrauma patients were represented by extremities’ fractures and abdominal injuries. Regarding the associated injuries, 30% from the Antiox group and 78.5% from the Contr group had suffered head injuries, 80% of patients from Antiox group and 71.4% of patients from the Contr group suffered thoracic injuries. Every patient’s data regarding days of mechanical ventilation, ICU length of stay and mortality were also recorded.įifty percent of patients from the Antiox group and 57.1% from the Contr group were admitted to the ICU following a road accident. Subsequently, the humoral-biochemical markers were analyzed once every 24 hours until the moment of discharge from the ICU. All patients received biological investigations conducted by the central laboratory of the hospital and ICU own laboratory during the stay in ICU. Clinical and demographic characteristics that were also recorded at admission in ICU included: gender, age, ISS, Apache II score, Glasgow Coma Scale (GCS) score < 7, invasive or noninvasive blood pressure, heart rate (HR), SpO 2, base excess (BE), lactate (Lac), temperature, haemoglobin (Hb), thrombocytes, leukocytes, international normalized ratio (INR), activated partial thromboplastin time (APTT), prothrombin time (PT), lactate dehydrogenase (LDH), urea, aspartate transaminase (AST), alanine transaminase (ALT) values. Duration of mechanical ventilation, the ICU length of stay and the mortality rate were secondary endpoints.įrom patients files we collected data concerning the trauma mechanism, associated injuries, admission module (direct admission/transfer from another hospital), the admission speed in ICU “Casa Austria” and the transfusional requirements. The aim of our study was to identify possible relations between antioxidant therapy and the laboratory tests measured before and after therapy, in patients with critically trauma and hemorrhagic shock. Īntioxidant therapy significantly reduces ischemia-reperfusion injuries and correlated with a significant decrease of mortality in critically ill patients. Several studies have shown beneficial effects from the intravenous administration of antioxidants (AOX) (vitamin C, vitamines B, N-acetylcysteine) in patients with critically trauma and hemorrhagic shock. Hemorrhagic shock is associated with an increased level of FR, mainly due to ischemia-reperfusion syndrome. In physiological conditions, the human body has an antioxidant autonomous system consisting of numerous enzymes and biomolecules able to interrupt the oxidative activity of FR: superoxide dismutase, catalase, glutathione, uric acid, methionine.
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Patients with critical trauma have a drastically increased production of free radicals (FR). The production of reactive oxygen or nitrogen species occurs in the human body under normal circumstances.
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